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Recombinant Mouse CTLA4 Protein (Fc Tag)(Active)
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Recombinant Mouse CTLA4 Protein (Fc Tag)(Active)

    Original price was: $140.99.Current price is: $43.99.

    Recombinant Mouse CTLA4 Protein (Fc Tag)(Active)
     

    SKU #
    PKSM041002

    Expression Host
    HEK293 Cells

     
     
    Description

    Synonyms
    CD152, CTLA-4, Ctla4 , Cytotoxic T-lymphocyte protein 4, Cytotoxic T-lymphocyte-associated antigen 4

    Species
    Mouse

    Expression Host
    HEK293 Cells

    Sequence
    Ala37-Asp161

    Accession
    P09793

    Calculated Molecular Weight
    40.4 kDa

    Observed Molecular Weight
    50-60 kDa

    Tag
    C-Fc

    Bio-activity
    Loaded Human B7-2-His on HIS1K Biosensor, can bind Mouse CTLA-4-Fc with an affinity constant of 5.65 nM as determined in BLI assay. 

      

     
    Properties

    Purity
    > 95 % as determined by…

    In stock
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    SKU: 2k0rurq

      Recombinant Mouse CTLA4 Protein (Fc Tag)(Active)

       

      SKU # PKSM041002
      Expression Host HEK293 Cells

       

       

      Description

      Synonyms CD152, CTLA-4, Ctla4 , Cytotoxic T-lymphocyte protein 4, Cytotoxic T-lymphocyte-associated antigen 4
      Species Mouse
      Expression Host HEK293 Cells
      Sequence Ala37-Asp161
      Accession P09793
      Calculated Molecular Weight 40.4 kDa
      Observed Molecular Weight 50-60 kDa
      Tag C-Fc
      Bio-activity Loaded Human B7-2-His on HIS1K Biosensor, can bind Mouse CTLA-4-Fc with an affinity constant of 5.65 nM as determined in BLI assay. 

        

       

      Properties

      Purity > 95 % as determined by reducing SDS-PAGE.
      Endotoxin < 1.0 EU per μg of the protein as determined by the LAL method.
      Storage Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
      Shipping This product is provided as lyophilized powder which is shipped with ice packs.
      Formulation Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
      Normally 5% – 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.
      Please refer to the specific buffer information in the printed manual.
      Reconstitution Please refer to the printed manual for detailed information.
      Background
      Mouse Cytotoxic Tlymphocyte 4(CTLA-4,CD152), is a type I transmembrane T cell inhibitory molecule. Within the ECD, Mouse CTLA-4 shares 68% aa sequence identity with human. CTLA4 is similar to the T cell costimulatory protein CD28 since both of the molecules bind to CD80 and CD86 on antigen-presenting cells. CTLA4 transmits an inhibitory signal to T cells, whereas CD28 transmits a stimulatory signal. Intracellular CTLA4 is also found inregulatory T cells and may play an important role in their functions. T cell activation through the T cell receptor and CD28 leads to increased expression of CTLA4. Genetic variations of CTLA4 have been associated with susceptibility to systemic lupus erythematosus(SLE), Gravesdisease(GRD), Celiac disease type3(CELIAC3) and Hepatitis B virus infection(HBVinfection).

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